The Temple Lung Center conducts one of the most comprehensive lung disease clinical trials programs in the country. Our advancements in basic, translational and clinical research are changing lung disease treatment. By pioneering effective therapies, we bring hope to patients with serious and debilitating lung diseases.
Review Our Open Clinical Trials
Asthma
Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Mediumto-High Dose Inhaled Corticosteroids (Umbriel)
NCT06932263
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma (ATLAS)
NCT05097287
A Dose Finding Study With an Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled Asthma
NCT06748053
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
NCT06979323
A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/?Albuterol Sulfate is Effective in Preventing Asthma Exacerbations
NCT06052267
Pragmatic Open - Label Randomized Clinical Trial of FF/?UMEC/?VI vs Non-ellipta Usual Care ICS-LABA for Adult Participants With Uncontrolled Asthma
A Study to Evaluate Solriktug in Adult Participants With Asthma (RAINIER)
Bronchiectasis
A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis
COPD
REAL-world Effectiveness of Mepolizumab In TreaTIng Chronic Obstructive Pulmonary Disease: A Multi-Country Prospective Study (REALITI-C)
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Video Telehealth Pulmonary Rehabilitation to Reduce Hospital Readmission in Chronic Obstructive Pulmonary Disease
NCT05119556
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3 (BREATHE-3)
NCT06891755
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (EMBARK)
NCT06883305
Temple Health Chest Initiative (THCI 2.0) - Lung Cancer Screening Project With COPD Detection
Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema (ELEVAATE OLE)
NCT05897424
STRIVE Post-Market Registry Study
Device myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
NCT05204888
Biological Effects of Quercetin in COPD Phase II
An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema (CONVERT_II)
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease (THARROS)
A Study to Evaluate Solrikitug in Participants With COPD (ZION)
Interstitial Lung Disease (ILD)
A Study to Test Whether Nerandomilast Helps People With Lungfibrosis Related to Rheumatic Diseases
NCT06806592
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILDs)
NCT06388421
PH-ILD A Study of Mosliciguat in PH-ILD (PHocus)
NCT06635850
PH-ILD DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
NCT06388421
A Trial to Evaluate Efficacy and Safety of Buloxibutid in People With Idiopathic Pulmonary Fibrosis. (ASPIRE)
NCT06588686
A Study of the Efficacy and Safety of Belimumab in Adults With Interstitial Lung Disease Associated With Connective Tissue Disease (BEconneCTD-ILD)
NCT06572384
A Study to Test Whether BI 1819479 Improves Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF)
NCT06335303
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
NCT05943535
SSc-ILD A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease (BLISSc-ILD)
NCT05878717
Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension (MOMENTOUS)
NCT06911632
Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)
A Phase 2 Study of CAL101 in Patients With Idiopathic Pulmonary Fibrosis (AURORA)
NCT06736990
A Study Evaluating the Safety and Efficacy of AP01 in Participants With Progressive Pulmonary Fibrosis (PPF)
Inpatient
Trial of Therapeutic Hypothermia in Patients With ARDS (CHILL)
Lung Cancer
Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening (PROACT-LUNG)
Lung Transplant
A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction (ROCKaspire)
Mesothelioma
National Mesothelioma Virtual Registry and Tissue Bank (U19)
Pulmonary Vascular Disease
PH-ILD A Study of Mosliciguat in PH-ILD (PHocus)
NCT06635850
Endovascular Engineering ENGULF Study (ENGULF)
NCT05597891
PH-ILD DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
NCT06388421
Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System
NCT04798261
Novel alpha2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial (NAIL-IT)
NCT05408546PH-COPD MK-5475-013 INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of MK-5475 (an Inhaled sGC Stimulator) in Adults With PH-COPD
NCT05612035
PH-COPD The RAPID - PE Study: RESCUE Advanced Protocol for the Treatment of Pulmonary Embolism
NCT06433011
Sarcoidosis
Efficacy and Safety Study of OATD-01 in Patients With Active Pulmonary Sarcoidosis (KITE)
Other
